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Toru Kono Selected Research

gosha-jinki-gan

10/2021Effects of Goshajinkigan (TJ-107) for oxaliplatin-induced peripheral neurotoxicity using the functional assessment of cancer therapy/gynecologic oncology group 12-item neurotoxicity questionnaire in a Phase II, multicenter, randomized, double-blind, placebo-controlled trial.
11/2015Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats.
8/2015Preventive effect of Goshajinkigan on peripheral neurotoxicity of FOLFOX therapy (GENIUS trial): a placebo-controlled, double-blind, randomized phase III study.
1/2014Goshajinkigan, a traditional Japanese medicine, prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat.
12/2013Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, double‑blind, placebo‑controlled trial of goshajinkigan to prevent oxaliplatin‑induced neuropathy.
9/2013[Kampo medicine for the treatment of adverse effects caused by anticancer drugs].
8/2011The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen.
1/2011Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer.
12/2009Preventive effect of goshajinkigan on peripheral neurotoxicity of FOLFOX therapy: a placebo-controlled double-blind randomized phase II study (the GONE Study).
8/2007[A case of neurotoxicity reduced with goshajinkigan in modified FOLFOX6 chemotherapy for advanced colon cancer].

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Toru Kono Research Topics

Disease

16Neoplasms (Cancer)
04/2022 - 02/2004
14Colorectal Neoplasms (Colorectal Cancer)
04/2022 - 08/2007
8Stomatitis
03/2018 - 12/2010
8Colitis
02/2013 - 05/2003
7Colonic Neoplasms (Colon Cancer)
04/2022 - 08/2007
7Crohn Disease (Crohn's Disease)
06/2021 - 06/2007
4Mucositis
11/2020 - 05/2014
4Ileus
10/2017 - 09/2013
4Peripheral Nervous System Diseases (PNS Diseases)
11/2015 - 08/2011
3Inflammation (Inflammations)
04/2022 - 09/2014
3Hypesthesia (Numbness)
10/2021 - 08/2007
3Pain (Aches)
10/2021 - 09/2014
3Stomach Neoplasms (Stomach Cancer)
01/2018 - 04/2004
3Adenocarcinoma
07/2016 - 08/2010
3Liver Cirrhosis (Hepatic Cirrhosis)
01/2016 - 11/2011
3Pancreatic Neoplasms (Pancreatic Cancer)
08/2010 - 06/2008
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2022 - 01/2010
2Muscle Cramp (Cramp)
10/2021 - 11/2015
2Rectal Neoplasms (Rectal Cancer)
05/2021 - 10/2020
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2020 - 01/2016
2Gastroesophageal Reflux (GERD)
11/2020 - 03/2018
2Neoplasm Metastasis (Metastasis)
10/2020 - 12/2010
2Diarrhea
10/2017 - 09/2013
2Atrophy
01/2016 - 11/2015
2Fibrosis (Cirrhosis)
01/2016 - 01/2012
2Cold Hypersensitivity
01/2014 - 01/2012
1Dysbiosis
04/2022
1Arthralgia (Joint Pain)
10/2021
1Intestinal Volvulus (Volvulus)
07/2021
1Inguinal Hernia (Direct Inguinal Hernia)
07/2021
1Heartburn (Pyrosis)
11/2020
1Breakthrough Pain
10/2020
1Non-alcoholic Fatty Liver Disease
03/2020
1Obesity
03/2020
1Esophageal Neoplasms (Esophageal Cancer)
03/2018
1Metaplasia
03/2018
1Esophageal Squamous Cell Carcinoma
03/2018
1Necrosis
10/2016
1Rectovaginal Fistula
07/2016
1Biliary Atresia
01/2016
1Paresthesia (Dysesthesia)
11/2015

Drug/Important Bio-Agent (IBA)

11Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2021 - 08/2007
10gosha-jinki-ganIBA
10/2021 - 08/2007
912,13- dihydro- N- methyl- 6,11,13- trioxo- 5H- benzo(4,5)cyclohepta(1,2- b)naphthalen- 5,12- imineIBA
04/2022 - 10/2011
6Dinoprostone (PGE2)FDA Link
11/2020 - 05/2014
5hange-shashintoIBA
03/2018 - 12/2010
4Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
07/2015 - 05/2003
4AdrenomedullinIBA
02/2013 - 06/2010
3AcidsIBA
11/2020 - 06/2010
2Acetic Acid (Vinegar)FDA LinkGeneric
04/2022 - 05/2003
2Bevacizumab (Avastin)FDA Link
05/2021 - 10/2013
2Pharmaceutical PreparationsIBA
03/2020 - 09/2013
2EnzymesIBA
03/2018 - 02/2008
2Proteins (Proteins, Gene)FDA Link
10/2016 - 01/2012
2Infliximab (Remicade)FDA Link
07/2016 - 01/2013
2Fluorouracil (Carac)FDA LinkGeneric
08/2015 - 12/2010
2Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric
01/2014 - 01/2011
2Calcium Gluconate (CBG)IBA
01/2014 - 01/2011
2Cetuximab (Erbitux)FDA Link
10/2013 - 12/2010
2SonazoidIBA
09/2012 - 08/2010
2Thioacetamide (Thioacetamid)IBA
01/2012 - 11/2011
2ProstaglandinsIBA
12/2010 - 05/2003
2Peptides (Polypeptides)IBA
06/2010 - 01/2010
2Messenger RNA (mRNA)IBA
01/2010 - 06/2008
2Dextran SulfateIBA
01/2010 - 04/2004
2Nitric Oxide (Nitrogen Monoxide)FDA Link
04/2004 - 03/2002
1Volatile Fatty AcidsIBA
04/2022
1propionic acid (potassium propionate)IBA
04/2022
1tetra-4-amidinophenoxypropane (TAPP)IBA
07/2021
1Indocyanine Green (Cardio-Green)FDA LinkGeneric
06/2021
1Fentanyl (Sublimaze)FDA LinkGeneric
10/2020
1bofu-tsusho-sanIBA
03/2020
1InterleukinsIBA
01/2020
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
03/2018
1Chenodeoxycholic Acid (Chenix)FDA Link
03/2018
1Bile Acids and Salts (Bile Acids)IBA
03/2018
1Claudin-4IBA
10/2017
1Caspase 3 (Caspase-3)IBA
10/2017
1Interleukin-6 (Interleukin 6)IBA
10/2017
1OccludinIBA
10/2017
1AzoxymethaneIBA
01/2017
1ErbB Receptors (EGF Receptor)IBA
01/2017
1CateninsIBA
01/2017
1pyrazolanthroneIBA
10/2016
1JNK Mitogen-Activated Protein KinasesIBA
10/2016
1AntibodiesIBA
07/2016
1Toll-Like Receptor 4IBA
01/2016
1DNA (Deoxyribonucleic Acid)IBA
01/2016

Therapy/Procedure

15Drug Therapy (Chemotherapy)
11/2020 - 02/2004
10Kampo Medicine (Kampo)
03/2018 - 11/2008
8Therapeutics
10/2021 - 01/2008
3Traditional Medicine (Folk Remedies)
03/2020 - 04/2015
3Colectomy
07/2015 - 08/2007
2Oral Administration
01/2016 - 04/2004
1Ileostomy
04/2022
1Sutures (Suture)
07/2021
1Chemoradiotherapy
05/2021
1Anesthesia
07/2016
1Proctectomy
07/2016
1Ligation
01/2016